The instrument variable assumptions imply that all trains leaving the departure station (genetic variant) and arriving at the destination (outcome) must pass through the exposure station. They can ...

Mendelian randomization, a powerful tool in medical research, helps us understand whether certain factors truly cause disease. This technique uses genetic variations as "natural experiments" to reveal ...

The schematic illustrates the comprehensive pipeline for Mendelian randomization analysis, starting with multi-omics data inputs from GWAS, eQTL, and pQTL studies, sourced from major databases such as ...

The Mendelian randomization–based analysis, which examines how variation in genes have a causal effect of an exposure on certain outcomes, identified 12 gut microbiota associated with either an ...

NO2 exposure is linked to ovarian cancer, with Mendelian randomization and meta-analysis confirming its role as a risk factor. The study utilized data from FinnGen R10 and OpenGWAS databases, showing ...

Please provide your email address to receive an email when new articles are posted on . Exposure to nitrogen oxides increased risks for rheumatoid arthritis, Sjögren’s and systemic lupus erythematosus ...