The accurate annotation of protein function is key to understanding life at the molecular level and has great biomedical and pharmaceutical implications. However, with its inherent difficulty and ...
Gain-of-function research (GOFR) refers to the serial passaging of microorganisms to increase their transmissibility, virulence, immunogenicity, and host tropism by applying selective pressure to a ...
A decade ago, scientists funded by the National Institutes of Health used ferrets to engineer a highly lethal flu virus. The purpose of the research — known as “gain of function” — was to better ...
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