How does the cell convert DNA into working proteins? The process of translation can be seen as the decoding of instructions for making proteins, involving mRNA in transcription as well as tRNA. But ...

Transcription and translation are processes a cell uses to make all proteins the body needs to function from information stored in the sequence of bases in DNA. The four bases (C, A, T/U, and G in the ...

Nascent polypeptide chains or polypeptidyl-tRNAs (pep-tRNAs) occur transiently during protein synthesis. The potential to study these intermediates and better understand their role in processes like ...

RNA, widely known from the COVID-19 vaccine, is not actually a "therapeutic agent," but a technology that delivers the ...

Proteins are essential biological molecules that perform a vast array of functions crucial for life, from catalyzing biochemical reactions and transporting molecules to providing structural support ...

Translation factors eIF1A and eIF5B are key repressors of an abnormal protein translation process linked to neurodegenerative disorders, as reported ...

For researchers studying how proteins can cause human disease, knowing precisely where proteins are made within cells and tissues could help them learn about their role in disease and come up with new ...

Aging selectively impairs the production of crucial DNA- and RNA-binding proteins, which contributes to hallmarks of aging in the brains of killifish, according to a new study. The findings advance ...

A team has recreated the harmful RAN translation process triggered by C9orf72 repeat expansions in ALS and FTD. Using a fully ...

In an effort to reveal the inner workings of a protein that serves as a cell's damage detection system, scientists at Johns Hopkins and the Ludwig-Maximilians-University Munich (LMU) have published ...