Order of genetic mutations shapes cancer's development and patient outcomes

In many aspects of our lives, we find meaning in the order in which events occur. We buy into myths about "middle child syndrome," talk of calm before storms, and consider it strange to start a meal ...

Childhood leukemia aggressiveness depends on timing of genetic mutation, research reveals

A team of researchers at the Icahn School of Medicine at Mount Sinai has uncovered why children with the same ...
Phys.org

'Silent' mutations found to have repercussions beyond their own gene

Genetic disorders—like cystic fibrosis and Huntington's disease—are considered incurable, with gene mutations occurring in essentially every cell of the body. Gene mutations occur when one nucleotide ...
ascopubs.org

Codon-specific KRAS mutations predict overall survival benefit of trifluridine/tipiracil in metastatic colorectal cancer.

RAS co-mutation and early onset disease represent an aggressive phenotype of atypical (non-V600) BRAF mutant metastatic colorectal cancer. Biweekly mXELIRI versus FOLFIRI in combination with ...
The Scientist

The Origins and Recent Promise of Nonsense Suppressor tRNAs

Between 10 to 15% of all genetic diseases have the same underlying cause: a nonsense mutation. 1 This type of mutation results from a stop codon in the middle of a gene sequence, which terminates ...
WebMD

EGFR Mutations in NSCLC: What Does It Mean?

Epidermal growth factor receptor (EGFR) is a protein on the surface of your cells that helps them grow. When the gene that codes for EGFR has a mutation, it affects the way this protein works, causing ...