It’s been a much different year for the 49ers, who have dealt with major injuries on both sides of the ball, including season ...

The Indianapolis Colts have gone 1-5 in their last six games. Key players at impact positions are now out, and the team is ...

"GMFB" debate are the San Francisco 49ers a serious threat in the NFC. "GMFB" share their takeaways from Los Angeles Rams ...

Fred Warner's wife Sydney is leaning on an unexpected group of women as she prepares to welcome her second child. The All-Pro ...

The Buffalo Bills are favored by 10 points over the Cleveland Browns, but have been upset twice this season as big favorites.

San Francisco could suddenly be a dark-horse team to win the NFC West and get the conference's No. 1 overall seed.

The San Francisco 49ers won't play their Week 16 game until Monday night, but they've already benefitted from a massive game ...

Mike Florio is picking the 49ers to win by a touchdown, while Chris Simms is taking San Francisco by 15. "The Colts have ...

It wasn't just the Seahawks celebrating Thursday's night win. The 49ers now have a path to the NFC West title, too.

The 49ers (10-4) have a better shot at the NFC’s No. 1 seed and a potential Super Bowl home game thanks to the Seattle ...

See who's in and who's out for the Week 16 matchup between the San Francisco 49ers and Indianapolis Colts on December 22, ...

INDIANAPOLIS — The Indianapolis Colts and San Francisco 49ers understand the stakes on Monday night. Both find themselves in ...